September 22, 2021
Friends of Physiology Lecture19:00 – 19:30 EST
Welcome and Opening Remarks
Crina Nimigean, President, Society of General Physiologists
Stefan Feske, Conference Organizer
Introduction by Richard Lewis, PhD, Stanford University, Stanford, CA
Keynote Address19:30 – 20:30 EST
Ion Channels in T Lymphocytes: A Single Cell Approach to Immunology
Michael Cahalan, PhD
University of California, Irvine, CAVIRTUAL TALK
September 23, 2021
Session 1: Ion Channels & Transporters (ICTs) in Lymphocytes
8:00-10:00 EST
NAADP and Ca2+ Signaling in T Cells
Andreas Guse, MD
University Medical Center Hamburg-Eppendorf, Hamburg, GermanyVIRTUAL TALK
TRPM7 and Other Ion Channels in B Cell Function
Bebhinn Treanor, PhD
University of Toronto Scarborough, CanadaVIRTUAL TALK
CRAC Channels in B-cells
Mohamed Trebak, PhD
University of Pittsburgh, Pittsburgh, PA
NKD2 Regulates ORAI1 Trafficking and CRAC Channel Function
Yousang Gwack, PhD
David Geffen School of Medicine at UCLA, Los Angeles, CA
Data Blitz 1
4 Snapshot Poster PresentationsVIRTUAL TALK
Session 2: ICTs in Innate Immunity 110:30-11:55 EST
TRPM2, Linking Oxidative Stress and Ca2+ Permeation to NLRP3 Inflammasome Activation
Longfei Wang, PhD
Harvard Medical School, Boston, MAVIRTUAL TALK
Mitochondrial Ca2+ Signaling in Cell Intrinsic Immune Responses
Bimal Desai, PhD
University of Virginia, Charlottesville, VA
Orai Channel C-terminal Peptides – Calcium Signal Suppression and Potential for Immunomodulation
Donald Gill, PhD
Penn State University, State College, PA
The Volume Regulated Anion Channel LRRC8C Suppresses T Cell Function by Regulating Cyclic Dinucleotide Transport and STING-p53 Signaling
Axel Concepcion, PhD
New York University, New York, NY
Data Blitz 2
4 Snapshot Poster Presentations
Round Table 114:00-15:00 EST
Career Development and Increasing Diversity
Poster Session 1, In-Person15:00-17:00 EST
Authors at Posters for discussion with attendees
Session 3: Novel Structures of ICTs in Immune Cells19:00-21:00 EST
Mechanosensation by PIEZO1 Is Essential for Innate Immunity
Angel Solis, PhD
Gettysburg College, Gettysburg, PA
Structural Studies Reveal Insights into CRAC Channel Activation
Xiaowei Hou, PhD
Memorial Sloan Kettering Cancer Center, New York, NY
The Mitochondrial Calcium Uniporter: Pore Structure and Regulation by MICU1/MICU2
Stephen Long, PhD
Memorial Sloan Kettering Cancer Center, New York, NY
Ligand Recognition and Gating Mechanism of Temperature Sensitive TRPM Channels
Juan Du, PhD
Van Andel Institute, Grand Rapids, MIVIRTUAL TALK
September 24, 2021
Session 4: ICTs in Lymphocytes and Antitumor Immunity8:15-10:00 EST
Potassium Channel Role in Anti-tumor Immunity
Laura Conforti, PhD
University of Cincinnati, Cincinnati, OHVIRTUAL TALK
Synthetic Biology Approaches to Regulate T Cell Mediated Immunity to Cancer
Yubin Zhou, MD, PhD
Center for Translational Cancer Research, Texas A&M, Houston, TXVIRTUAL TALK
Otopetrin Proton Channels: What, Where, Why and How
Emily Liman, PhD
University of Southern California, Los Angeles, CA
Regulation of Immune Cell Function by Ion Channels
Stefan Feske, MD
NYU Grossman School of Medicine, New York, NY
Session 5: ICTs in Innate Immunity 210:30-12:10 EST
Under-appreciated Role of Mechanotransduction in Vivo
Shang Ma, PhD
University of California, San Diego, CA
Membrane Potential Modulates Neutrophil Calcium Signaling in Development and Inflammation
Regina Clemens, MD, PhD
Washington University School of Medicine, St. Louis, MO
Calcium-dependent and Independent Roles of Membrane Contact Sites During Phagocytosis
Paula Nunes-Hasler, PhD
University of Geneva, Geneva, SwitzerlandVIRTUAL TALK
Endolysosomal TRP Channels and TPCs in Immune Cell Function and Disease
Christian Grimm, PhD
Ludwig-Maximilians-University Munich, GermanyVIRTUAL TALK
Data Blitz 3
5 Snapshot Poster PresentationsVIRTUAL TALK
Round Table 214:00-15:00 EST
Ion Channels & Transporters as Drug Targets in Immunity and Inflammation
Poster Session 215:00-17:00 EST
Authors at Posters for discussion with attendeesVIRTUAL SESSION
Session 6: Cell Biological Aspects of ICTs in Immune Cells19:00-21:00 EST
Lipid Regulation of Monovalent Channels in Immune Surveillance
Sergio Grinstein, PhD
Hospital for Sick Children, Toronto, CanadaVIRTUAL TALK
Interplay Between KCa1.1 and Cav1.2 Channels in Synovial Fibroblasts in Rheumatoid Arthritis
Christine Beeton, PhD
Baylor College of Medicine, Houston, TXA
TRPM2 During The Inflammatory Response of Phagocytic Cells: Friend or Foe
Santiago Partida-Sanchez, PhD
Abigail Wexner Research Institute at Nationwide Children's Hospital & The Ohio State University College of Medicine, Columbus, OH
Suppression of Ca2+ Signals by EGR4 Controls Th1 Differentiation and Anti-cancer Immunity In Vivo
Jonathan Soboloff, PhD
Temple University, Pennsylvania, PA
Mechanically Activated Ion Channel Piezo1 Modulates Macrophage Polarization and Stiffness Sensing
Wendy Liu, PhD
University of California, Irvine, CAVIRTUAL TALK
Method of Measuring the Membrane Potential of Phagosomes by Optical Imaging
Yoshifumi Okochi, PhD
Osaka University, JapanVIRTUAL TALK
September 25, 2021
Session 7: Pathophysiological Roles of ICTs in Inflammation8:00-10:00 EST
Pannexin-1 Channels Promote Neuroinflammation After Brain Trauma
Jorge Contreras, PhD
The University of California Davis, Sacramento, CA
Microglial CRAC Channels and Neuroinflammation
Murali Prakriya, PhD
Northwestern University, Chicago, IL
Solute Carrier Proteins in Macrophages Enable Efferocytosis by Promoting Glucose Uptake and Lactate Release
Kodi Ravichandran, PhD
University of Virginia, Charlottesville, VAVIRTUAL TALK
Ezyme-coupled TRP Channels and Endolysosomal TPCs in Immune Homeostasis
Susanna Zierler, PhD
Johannes Kepler University Linz, AustriaVIRTUAL TALK
Session 8: Modulation of Immune Cell Function by ICTs10:30-12:00 EST
Ion Channels Regulating Neural-Immune Interactions in Host Defense and Immunity
Isaac Chiu, PhD
Harvard Medical School, Boston, MA
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-induced Inflammation
Asrar Malik, PhD
University of Illinois at Chicago, Chicago, ILVIRTUAL TALK
cGAMP as an Immunotransmitter and its Transporters
Lingyin Li, PhD
Stanford University, Stanford, CAVIRTUAL TALK
Session 9: Ion Channels as Drug Targets in Immune Diseases17:00-18:45 EST
CRAC Channels in Mast Cell Function and Allergy
Anant Parekh, PhD
Oxford University, EnglandVIRTUAL TALK
Illuminating Dark and Druggable Genome
Olga Gulyaeva, PhD
University of California, San Francisco, CA
Targeting TRP Channels for Immune Modulation
Andrea Fleig, PhD
University of Hawaii Cancer Center, Honolulu, HI
CRAC Channels as Targets for Drug Discovery and Development
Kenneth Stauderman, PhD
CalciMedica, Inc. La Jolla, CA